At the FIFA World Cup 2018 draw that was made on Saturday in St Petersburg, Russia, Luxembourg was drawn in Group A along with Belarus, Bulgaria, Sweden, France and The Netherlands.

On Sunday, all qualifying fixtures were agreed and announced, as follows:

- Wed 6 September 2016: Bulgaria - Luxembourg
- Fri 7 October 2016: Luxembourg - Sweden
- Mon 10 October 2016: Belarus - Luxembourg
- Sun 13 November 2016: Luxembourg - The Netherlands
- Sat 25 March 2017: Luxembourg - France
- Fri 9 June 2017: The Netherlands - Luxembourg
- Thu 31 August 2017: Luxembourg - Belarus
- Sun 3 September 2017: France - Luxembourg
- Sat 7 October 2017: Sweden-Luxembourg
- Tue 10 October 2017: Luxembourg - Bulgaria

All games start at 20:45.