On Thursday 5 February 2026, Luxembourg's Ministry of the Economy and the Luxembourg National Research Fund (FNR) announced the nine projects selected for co-financing under the joint call for projects "High-Performance Computing and Artificial Intelligence", following the final phase of the selection process.
This joint call for projects was launched together with Luxinnovation in spring 2025 via the research-industry collaboration platform.
The objective of this call for projects was to accelerate the use of artificial intelligence (AI) and / or high-performance computing (HPC) within Luxembourg's innovation ecosystem, with a particular focus on AI applied to industry and scientific innovation, HPC for advanced simulations and data processing, and multidisciplinary projects combining AI and HPC.
The joint call aimed to encourage collaborative research and development projects in the form of public-private partnerships, by offering financial support to companies and research organisations to foster the development of new applications, services and technological capabilities that leverage the potential of AI and HPC for the benefit of society.
The selection process took place in several stages. In the final phase, seventeen consortia submitted complete project proposals, which were evaluated by a panel of independent experts. Following this evaluation, nine projects were selected to receive funding.
Selected Projects
AID-Care: The Artificial Intelligence for Neurodegenerative Diseases Care (AID-Care) project, proposed by NTT Luxembourg PSF SA in collaboration with the Luxembourg Centre for Systems Biomedicine (LCSB) at the University of Luxembourg, uses AI to transform unstructured medical records into interoperable datasets on dementia, thereby enabling personalised care and advancing research in Luxembourg and Japan.
Total budget: €1.806 million
NEURESA: The Neuro-Symbolic Reasoning for Embedded System Architectures Design (NEURESA) project, proposed by COGNIFYER and the University of Luxembourg, aims to develop intelligent, agent-based computer-aided design (CAD) software that integrates AI-based modelling, natural language interfaces, neuro-symbolic constraint resolution and GPU-accelerated computing. This is expected to enable users to design complex electronic systems for cars more efficiently, reliably and accessibly.
Total budget: €1.135 million
EASE: WEO and the Luxembourg Institute of Science and Technology (LIST) are collaborating on the EASE project, which aims to address the growing climate resilience challenges facing cities. By combining HPC with advanced super-resolution (SR) and explainable AI (XAI) techniques, the project improves the quality of freely accessible satellite data, enabling more precise and interpretable environmental monitoring despite the limitations of expensive high-resolution imagery.
Total budget: €1.11 million
Gravity-AI: The goal of this collaborative project between the Luxembourg Centre for Systems Biomedicine (LCSB) at the University of Luxembourg and Exobiosphere is to develop an integrated platform combining simulated microgravity experiments (i.e. experiments conducted as if they were taking place in space) with AI and HPC for the physiological modelling of Parkinson's disease.
Total budget: €1.434 million
GenePPS: The Gene Perturbation Prediction Systems (GenePPS) project, proposed by Helical and the University of Luxembourg, aims to develop hybrid AI models combining graphical neural networks and basic models to predict the effects of gene perturbation, reduce experimental costs and accelerate precision medicine and drug discovery.
Total budget: €931,000
CLAIRE: In collaboration with the Interdisciplinary Centre for Security, Reliability and Trust (SnT) at the University of Luxembourg, Hydrosat is implementing a project to make satellite-to-ground data transmission more efficient and cost-effective. It is developing an AI-powered, end-to-end cloud detection and compression system for infrared thermal Earth observation images, using HPC to enable satellites to transmit data to the ground more efficiently while using less energy and bandwidth.
Total budget: €1.423 million
AI4Kids: The joint project, AI4Kids: Norm-First & HPC-Verified Interactive Agents for Child-facing Applications, by LuxAI and the University of Luxembourg, aims to develop a child-centred AI framework that integrates prescriptive generative AI, goal-oriented planning and explainable decision-making to ensure safe, paedagogically appropriate and compliant interactions for children in sensitive settings such as education and healthcare.
Total budget: €1.666 million
RAISE: Orange Communications Luxembourg, in collaboration with the Luxembourg Institute of Science and Technology (LIST), is leading the collaborative project RAISE: Radio Access Intelligence for Saving Energy. This project aims to design and test AI-based methods that reduce the energy consumption of mobile radio access networks while maintaining a high quality of service for users. To achieve this, the partners are using data-driven modelling and digital twin simulations to evaluate and optimise network performance under real-world conditions.
Total budget: €1.309 million
HISEED: Paul Wurth SA, in collaboration with the University of Luxembourg, is working on a project that focuses on a major sustainability challenge: reducing carbon emissions in iron production. The HISEED: High-Fidelity Multiphase CFD Simulations for Hydrogen-Based Iron Ore Reduction in Circulating Fluidised Beds project aims to establish a simulation framework capable of accurately modelling the direct reduction process of iron ore using hydrogen in circulating fluidised bed reactors. To achieve this, it uses detailed fluid flow simulations supported by HPC.
Total budget: €773,000
Luxembourg's Minister of the Economy, SMEs, Energy and Tourism, Lex Delles, commented: "The results of this joint call for projects demonstrate the remarkable dynamism of our innovation ecosystem. By supporting projects that use artificial intelligence and high-performance computing, we are strengthening the competitiveness of businesses and research centres, while helping to accelerate Luxembourg's digital sovereignty. The selected projects perfectly illustrate our desire to encourage public-private partnerships, stimulating innovation in the fields of AI and HPC for the benefit of society."
Dr Isabelle Mossong, Secretary General of the FNR, stated: "For the FNR, this joint call for proposals demonstrates the value of bringing together scientific excellence and industrial ambition. The funded projects highlight how research and industry can jointly push the boundaries of what AI and HPC can achieve when expertise is shared and challenges are tackled collaboratively. These results show that Luxembourg's research community is ready to translate advanced knowledge into meaningful innovation, strengthening our capacity to address complex societal and economic needs. We are pleased to support partnerships that not only advance science but also reinforce Luxembourg's position as a hub for impactful, mission-driven research."
Mario Grotz, CEO of Luxinnovation, added: "The quality of the selected projects demonstrates, on the one hand, the dynamism of our entire ecosystem and, on the other hand, the strong complementarity between the various stakeholders involved. Supported by a robust digital infrastructure, in which the MeluXina supercomputer is a key component, and accompanied by highly specialised and recognised research expertise, companies and startups benefit from powerful support to develop and deliver innovative products and services. By facilitating such connections between public and private actors, we are activating a key lever of innovation."
The planning of the joint calls for projects for 2026 and 2027 is available online. In line with the government's strategic initiative "Accelerating Digital Sovereignty 2030", a joint call for projects in the fields of data, artificial intelligence (AI) and / or quantum computing will be open for submission from Sunday 1 March 2026.
